34 on Antiviral Research (ICAR)


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ICAR

2021

VIRTUAL
PROGRAM

CONFERENCE
and ABSTRACTS

34 th International Conference on Antiviral Research (ICAR) Hosted by the International Society for Antiviral Research (ISAR)

TABLE of CONTENTS

ORGANIZATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 VIRTUAL CONFERENCE INFO . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 SPECIAL EVENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 SCHEDULE at a GLANCE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 ISAR 2021 AWARDEES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 THE 2021 CHU FAMILY FOUNDATION SCHOLARSHIP AWARDEES . . . . 14 INVITED SPEAKER BIOGRAPHIES . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 PROGRAM SCHEDULE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 POSTERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 ABSTRACTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 AUTHOR INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110

PROGRAM and ABSTRACTS of the 34th International Conference on Antiviral Research (ICAR)

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ISAR ORGANIZATION

OFFICERS
PRESIDENT Kara Carter Boston, MA, USA

PRESIDENT ELECT Kathie Seley-Radtke Baltimore, MD, USA

PAST PRESIDENT Johan Neyts
Leuven, Belgium

TREASURER Brian Gowen Logan, UT, USA

SECRETARY Jinhong Chang Doylestown, PA, USA

Chris Meier Hamburg, Germany
Joana Rocha-Pereira Leuven, Belgium

BOARD OF DIRECTORS
María-Jesús Pérez-Pérez Madrid, Spain
Luis Schang Ithaca, NY, USA

Pei-Yong Shi Galveston, TX, USA
Subhash Vasudevan Singapore

THE INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH (ISAR)
The Society was organized in 1987 as a non-profit scientific organization for the purpose of advancing and disseminating knowledge in all areas of antiviral research. To achieve this objective, the Society organizes an annual meeting, The International Conference on Antiviral Research (ICAR). The Society, now in its 34th year of existence, has members representing 30 countries. To become an ISAR member, visit our website at www.isar-icar.com.

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ISAR ORGANIZATION

COMMITTEE CHAIRS

Archive Committee
Brian Gentry

Career Development Committee Leen Delang

Communications & Outreach Committee Kathie Seley-Radtke

Website Workgroup Andrea Brancale

Social Media Workgroup Jessica Spengler

Webinars Workgroup Raj Kalkeri

Publication Workgroup Luis Schang

Ambassadors Program Raj Kalkeri, Luis Schang and Pei-Yong Shi

Conference Exhibitors Committee Roger Ptak

Diversity Committee Ann Kwong

Finance Committee Roger Ptak
Poster Award Committee Brian Gentry
Scientific Excellence Awards Committee
Richard Whitley

Nominations Committee Johan Neyts
Program Committee Katherine Seley-Radtke Abstract Review Workgroup Justin Julander and Joana Rocha Pereira
The Chu Family Foundation Scholarship for Women Scientists Committee Kathie Seley-Radtke

Women In Science Committee Rhonda Cardin

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CONTRIBUTORS Confirmed sponsors as of March 15, 2021

GOLD *

GRANT FUNDING
provided by:

Burroughs Wellcome Fund

Gilead Sciences

Research Triangle Park, NC, USA

Foster City, CA, USA

(for Gertrude Elion Memorial Award)

(for Antonín Holý Memorial Award)

Aligos Therapeutics, Inc.
San Francisco, CA, USA
Dewpoint Therapeutics
Boston, MA, USA

SILVER

Emergent BioSolutions
Gaithersburg, MD, USA
JCR Pharmaceutical Co.
Ashiya, Japan

Ark Biosciences Inc.
Shanghai, China

BRONZE

FUJIFILM Toyama Chemical Co., Ltd.
Tokyo, Japan

Institute for Antiviral Research, Utah State University
Logan, UT, USA
XpressBio
Frederick, MD, USA

Oxeltis
Montpellier, France
University of Minnesota, Center for Drug Design
Minneapolis, MN, USA
ViroVet
Leuven, Belgium

Additional support provided by:

Journal of General Virology

Sage Publishing

(for Graduate and Post-doctoral Poster Awards)

(for Young Investigator Poster Awards)

*Supported by Gilead who provided funding. Gilead has had no input into the content of the materials used at this meeting/conference.

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VIRTUAL CONFERENCE INFORMATION
How do I access the virtual Conference?
Registered attendees will receive log-in details on Monday, March 15. The ICAR2021 virtual platform will work best with the latest version of Google Chrome. Please ensure you use Google Chrome to access the platform to minimize technical problems.
ICAR 2021 Virtual Platform Link:
https://portalapp.gravesshow.eventsair.com/VirtualAttendeePortal/icar/onair/login
When will Conference content be available?
All invited, oral and poster presentations will be prerecorded and available for on-demand viewing by registered attendees on Monday, March 15, 2021, one week ahead of the live Conference sessions. The selected format will allow attendees the opportunity to view those presentations as their own schedule permits.
When will live programming take place?
All scheduled times and dates for ICAR2021 live programming are listed in Eastern Standard Time and spread across two “global golden hours” from March 22 through March 26, 2021. If you are unable to attend the live programming, recordings will be posted on demand within 24-48 hours following the live session.
How long will Conference content be available to access?
All registered attendees will be able to access on-demand content from ICAR2021 through April 25, 2021.
What is the format for the Live Q&A Sessions?
There are 10 Live Q&A Sessions which will feature invited and short oral presenters. All talks will be prerecorded and available for viewing by conference attendees starting March 15. We highly encourage all attendees to view the talks prior to the live sessions. For each Live Q&A Session, the session chairs will provide a brief introduction and then each speaker will present a brief summary of their presentation. After all speakers have presented their summaries, the chairs will facilitate discussion amongst speakers and attendees. Attendees will have the option to use the Q&A board to ask questions in real-time.

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VIRTUAL CONFERENCE INFORMATION
What will a virtual poster session look like?
Posters will be divided into two groups: Poster Session 1 and Poster Session 2. During the Conference week, each poster group will present in TWO live sessions (A and B). During the live poster session, each poster presenter will have their own “room” where attendees and poster presenters will be able to speak with each other (presenter will be on video).
How do I interact with authors if I have questions?
Each presenter (invited, short oral and poster) will have a public chat message board on their page that will be monitored by the presenting author. Presenters are expected to check their chat board at least twice daily during the Conference week. We encourage attendees to leave feedback, questions, ask to be contacted for more information, or even leave a simple ‘hello’ to check in, so that they know you visited. The live sessions are another opportunity to interact in real-time.
Whom do I contact if I have problems?
For technical questions about accessing or using the platform: u While in the platform, click the “Live Support” button on the top menu bar just prior to or during
live sessions, or u Contact Mike Graves at [email protected] For questions about registration or other Conference items, please contact ICAR Staff at [email protected]
Where can I find out more information about ICAR2021 Virtual Conference?
Please visit our website and click on the Virtual Information Frequently Asked Questions page. This page will be updated frequently with details and tips for ICAR2021 to include various training videos to help you become familiar with the virtual platform.

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SPECIAL EVENTS

WOMEN IN SCIENCE ROUNDTABLE
Monday, March 22 • 12:15 – 1:15 PM ET
The Women in Science (WIS) Committee is excited to announce the 9th Annual Women in Science Roundtable. This year, our keynote speaker will be Dr. Akiko Iwasaki, professor at Yale University and an expert virologist and immunologist. Dr. Iwasaki is well known for her mentorship and addressing issues facing women in science, and most recently, the toll that Covid-19 has taken on women in particular. A 30-minute video presentation by Dr. Iwasaki will be available on March 15th for viewing prior to the live WIS session. This year’s live roundtable will provide an opportunity to reflect on Dr. Iwasaki’s presentation by participating in an important dialogue about the impact of theCOVID-19 pandemic on women in STEM. Attendees will have the opportunity to select a number of chat rooms with designated relevant topics to engage in important video chat discussions with other industry peers and professionals.

SPEED NETWORKING – TWO SESSIONS!
Monday, March 22 • 8:30 – 9:00 PM ET
Tuesday, March 23 • 11:45 AM – 12:15 PM ET
Ready to mix things up? Join us for these 30-minute sessions where you will be randomly
matched with a small group of attendees for FIVE minutes for a video chat. When time is up, you will be randomly matched with a new group of individuals, giving you the chance to meet people you have never met before, and to make some new lasting connections! Do not miss this interesting opportunity to mix things up in your social world.

CAREER DEVELOPMENT INTERACTIVE WORKSHOP
Tuesday, March 23 • 1:15 – 2:15 PM ET
You belong: finding confidence in the face of self-doubt and impostor syndrome
Prof. Jen Heemstra, Associate Professor, Emory University
“I don’t deserve to be here, and everybody knows it.” This is the constant messaging of impostor syndrome – whether you’re starting a new position, winning an award, or being asked to speak at a conference. While few of us talk about it, most of us experience it at some point in our careers. And, the struggles brought on by COVID-19 have only made this worse. However, with the right tools, we can fight back against impostor syndrome and help our friends and colleagues to do the same. This interactive workshop, given by Prof. Jen Heemstra, will explore the mechanisms by which thoughts of impostor syndrome can form, and how we can work to dismantle them.

PECKAKUCHA COMPETITION
Thursday, March 25 • 12:30 – 1:30 PM ET
Get ready to be entertained and informed! Join us for a fun session as seven finalists
present their PechaKucha presentations. Not famililar with PechaKucha? The presenter has 15 slides, each on the screen for only 20 seconds. The slides advance automatically and the presenter has to keep up, as they won’t have control. Be prepared for some humor, a few surprises and maybe something unexpected. Prizes will be awarded by a panel of judges to the top three finalists.

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SCHEDULE at a GLANCE *All times are listed in US Eastern Time.
All prerecorded presentations are available on-demand for registered attendees starting Monday, March 15, 2021.

11:00 AM – 12:15 PM ET
12:15 PM – 1:15 PM ET 7:30 PM – 8:30 PM ET 8:30 PM – 9:00 PM ET 9:00 PM – 10:00 PM ET
11:00 AM – 11:45 AM ET 11:45 AM – 12:15 PM ET 12:15 PM – 1:15 PM ET 1:15 PM – 2:15 PM ET 8:00 PM – 9:00 PM ET 9:00 PM – 9:45 PM ET
11:00 AM – 12:00 PM ET 12:00 PM – 12:45 PM ET 12:45 PM – 1:00 PM ET 8:00 PM – 9:00 PM ET 9:00 PM – 9:45 PM ET
11:00 AM – 11:45 AM ET 11:45 AM – 12:30 PM ET 12:30 PM – 1:30 PM ET 7:00 PM – 8:45 PM ET

MONDAY, MARCH 22, 2021
OPENING SESSION Q&A Session 1: Influenza/RSV Special Event: Women in Science Roundtable Poster Session 1A Speed Networking Session 1 Q&A Session 2: Pandemic Preparedness (dedicated to Mark Prichard) and Gertrude Elion Memorial Award
TUESDAY, MARCH 23, 2021
Q&A Session 3: COVID-19 Vaccines Speed Networking Session 2 Poster Session 2A Special Event: Career Development Interactive Workshop Q&A Session 4: COVID-19 Therapeutics and Diversity Speaker Award Q&A Session 5: Retroviruses and Herpes Viruses
WEDNESDAY, MARCH 24, 2021
Poster Session 1B Q&A Session 6: Other Viruses and Women in Science Speaker Award ISAR Annual Business Meeting Poster Session 2B Q&A Session 7: Arboviruses
THURSDAY, MARCH 25, 2021
Q&A Session 8: Hepatitis Viruses and William Prusoff Memorial Award Q&A Session 9: Technology and Antonín Holý Memorial Award Special Event: PechaKucha Competition Q&A Session 10: Other Respiratory Viruses CLOSING SESSION

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ISAR 2021 AWARDEES

GERTRUDE ELION MEMORIAL AWARDEE
William Lee, PhD
Defining innovation in the quest for treatment, prevention and cure of viral diseases
Dr. William “Bill” Lee is the Executive Vice President of Research at Gilead Sciences. He received his BS in Chemistry from the University of Massachusetts at Amherst and a PhD in Organic Chemistry with Teddy Traylor from the University of California San Diego. He did postdoctoral work in photocatalysis with Michael Gräzel at the EPFL in Switzerland and in bio-organic chemistry with Tom Bruice at the University of California Santa Barbara. He began his industry career at Syntex Research in Palo Alto, California and then moved to California Biotechnology where he was head of Drug Delivery. In 1991 he joined Gilead Sciences as Director of Pharmaceutical Product Development and became head of Discovery Research in 2000. During his tenure, Gilead has radically changed the paradigm for both treatment and prevention of HIV, launching multiple single-tablet regimens; discovered and developed curative antiviral regimens for HCV; and in 2020, received approval for the first antiviral drug, Veklury® against the SARS 2 virus. Dr. Lee is a co-inventor of Cellcept®, Viread® and tenofovir alafenamide, a lymphatic targeting prodrug of tenofovir, approved for the treatment and prevention of HIV in the combination products Genvoya®, Descovy®, Biktarvy®; Odefsey® and Symtuza® and as a solo product, Vemlidy® for the treatment of HBV®.
DIVERSITY SPEAKER AWARDEE
Craig Cameron, PhD
My career-long fascination with antiviral therapeutics
Craig E. Cameron is the Jeffery Houpt Distinguished Professor and Chair of the Department of Microbiology and Immunology at the University of North Carolina School of Medicine. He earned a Bachelor of Science degree in chemistry from Howard University in 1987. Following doctoral studies in biochemistry at Case Western Reserve University School of Medicine and post-doctoral studies in the chemistry department at Penn State, Cameron joined the faculty of biochemistry and molecular biology at Penn State in 1997. He was tenured, promoted to the rank of associate professor and appointed Louis Martarano Associate Professor in 2002. In 2005, he was promoted to the rank of professor and named the Paul Berg Professor of Biochemistry and Molecular Biology. From 2011-2012, Cameron served a two-year term as Associate Head for Research and Graduate Education. In 2013, he was named holder of the Eberly Family Chair in Biochemistry and Molecular Biology. Cameron moved to his current position in Chapel Hill in the fall of 2019. Cameron’s research focuses on RNA polymerases and RNA-binding proteins required for viral replication or mitochondrial function. The goal of this work is development of novel strategies to treat and/or prevent viral infections and mitochondrial dysfunction. During his career, Dr. Cameron has received several honors, including the Howard Temin Award from the National Cancer Institute, an Established Investigator Award from the American Heart Association, a Distinguished Service Award from the Eberly College of Science Alumni Association, the Genesis Scholar Award from HBCU Digest, Fellow of the American Association for the Advancement of Science, and Fellow of the American Academy of Microbiology. Cameron currently serves as an associate editor for Journal of Biological Chemistry and Science Advances. In July 2020, Cameron became president of the American Society for Virology.

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34 on Antiviral Research (ICAR)