School Of Biomedical Engineering Institute Of


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SCHOOL OF BIOMEDICAL ENGINEERING INSTITUTE OF TECHNOLOGY BANARAS HINDU UNIVERSITY

Revised Syllabus
Course Structure for Five Year Dual Degree (B. Tech. in Bioengineering and M. Tech. in Biomedical Technology)

Part II

3rd Semester:

________________________________________________________________________

Subject

Contact Hr. Credit

________________________________________________________________________

BM 2101 BM 2102 EE 2114 A AM 2101 MS 2101 AC 2101

Physiology-I Biochemistry Electrical Engineering Mathematical Methods Introduction to Material Science Chemistry of Polymers

3

3

3

3

3

3

3

3

3

3

3

3

Practical:

BM 2301 Biochemistry

3

2

BM 2302 Physiology-1

3

2

EE 2314 A Electrical Engineering

3

2

________________________________________________________________________

Total for third Semester

27

24

________________________________________________________________________

4th Semester:

________________________________________________________________________

Subject

Contact Hr. Credit

________________________________________________________________________

BM 2201 Physiology-II

3

3

BM 2202 Electronic Devices and Circuits

4

4

BM 2203 Biopotentials

3

3

BM 2204 Network Analysis and Synthesis

4

4

AM 2201 Numerical Analysis

3

3

MS 2203 Metals and Alloys

3

3

Practical

BM 2401: Physiology-II

3

2

BM 2402: Network Analysis and Electronic Circuits

3

2

AM 2401: Computer Lab

3

2

________________________________________________________________________

Total for Fourth Semester

29

26

________________________________________________________________________

1

Part III

5th Semester:

________________________________________________________________________

Subject

Contact Hr. Credit

________________________________________________________________________

BM 3101: Microprocessor and Microcontrollers

3

3

BM 3102: Electronic Circuits for Medical Instrumentation 3

3

BM 3103: Biomaterials

3

3

BM 3104: Pharmaceutical Microbiology

4

4

AC 3101: Analytical Techniques in Chemistry

3

3

MS 3106: Synthesis and processing of Materials

3

3

Practical:

BM 3301: Microprocessor and Microcontroller lab

3

2

BM 3302: Material Preparation lab

3

2

BM 3303: Polymer Material lab

3

2

________________________________________________________________________

Total for 5th Semester

28

25

________________________________________________________________________

6th Semester:

________________________________________________________________________

Subject

Contact Hr. Credit

________________________________________________________________________

Humanities*

3

3

BM 3201: Control System

3

3

BM 3202: Transducers and Instrumentation systems

3

3

AC 3201: Instrumental Methods for Chemical Analysis

4

4

MS 3210: Science of Ceramic Materials

3

3

EC 3204 Reliability Engineering

3

3

Practical:

PH 3402/: Microbiology Lab

3

2

BM 3403

BM 3401: Transducers and Instrumentation systems

3

2

BM 3402: Analytical Techniques in Chemistry

3

2

*Any one of the following open elective

1. HU 3201: History of Science and Technology

2. HU 3202: Industrial and Organizational Psychology

3. HU 3203: Intellectual Property Rights

4. HU 3204: Energy management

5. HU 3205: Industrial Sociology

6. HU 3206: Ethics, Philosophy and Values

7. HU 3207: Entrepreneurship Development

________________________________________________________________________

Total for 6th Semester

28

25

________________________________________________________________________

2

Part IV

7th Semester:

________________________________________________________________________

Subject

Contact Hr.

Credit

________________________________________________________________________

(UG)

BM 4101: Biological Control System Analysis 3

3

(PG)

BM 4102: Biomechanics

3

3

(PG)

BM 4103: Biomedical Instrumentation

3

3

(UG)

BM 4104: Molecular Biology and Genetics

3

3

(UG)

BM 4105: Transport Phenomena

3

3

Practical:

(UG)

BM 4301: Control System

3

2

(UG)

BM 4302: UG Project

6

4

BM 4303 Seminar

3

2

BM 4304 Training/Tour Viva-voce

-

2

________________________________________________________________________

Total for 7th Semester

27

25

________________________________________________________________________

8th Semester:

________________________________________________________________________

Subject

Contact Hr.

Credit

________________________________________________________________________

(UG) BM 4201: Biotransport Process

4

4

(UG) BM 4202: Radiation and Biomedical Applications 3

3

(PG) BM 4203: Biomedical Signal and Image Processing 3

3

(PG) BM 4204: Composite Materials

3

3

(UG) EC 4201: LSI/VLSI Design

3

3

Practical: (UG) BM 4401: (PG) BM 4402: (PG) BM 4403:
BM 4404

Biomedical Instrumentation Biomechanics Lab PG Project / Dissertation Comprehensive Viva-voce

3

2

3

2

6

4

-

2

________________________________________________________________________

Total for 8th Semester

28

26

________________________________________________________________________

3

Part V

9th Semester:

________________________________________________________________________

Subject

Contact Hr.

Credit

________________________________________________________________________

BM 5101: Computer Application in Biomedical Engineering 3

3

*Select any three electives

*BM 5102: Bioceramics

3

3

*BM5 103 Tissue engineering

3

3

*BM 5104: Advanced Biomechanics

3

3

*BM 5105: Rehabilitation Engg

3

3

*BM 5106: Bioinformatics

3

3

*BM 5107: Hospital system Management

3

3

*BM 5108: Mathematical methods in Biomedical Engg

3

3

*BM5109: Polymers in Medicine

3

3

*ME5114A: Industrial Management

3

3

Practical:

(PG) BM 5301 Computer Application Lab

3

2

BM 5302 Seminar on Dissertation

-

5

BM 5303 Dissertation Evaluation-1

9

5

________________________________________________________________________

Total for 9th Semester

24

24

________________________________________________________________________

One PG Open Elective from other Department may be taken

10th Semester ________________________________________________________________________

Subject

Contact Hr.

Credit

________________________________________________________________________

BM 5401 PG Seminar

2

1

BM 5402 Dissertation Pre Submission seminar

-

5

BM 5403 Dissertation Evaluation-II

-

10

________________________________________________________________________

2

16

________________________________________________________________________

Year wise credits

I Year

50

II Year

50

III Year 50

IV Year

51

V Year

40

Total credits 241

4

3rd – Semester
BM 2101: PHYSIOLOGY-I
Introduction to Human Physiology. Basic cell Structure, various cell organelles and their functions. Process of cell division. Tissues, their types, structure and functions. Organs and systems. Skin; basic structure and function
Hematology: Blood composition, properties and function. Structure and function of red blood cells, white blood cells and platelets. Blood transfusion. Hemostasis. Immune mechanisms.
Circulatory and Lymphatic System: Anatomy of the heart and the blood vessels. Heartposition and function. Origin of the heart beat and electrical activity of the heart. Arteries, capillaries and veins- structure and function. Cardiac and peripheral circulation. Blood pressure and its regulation. Blood flow and its regulation. Circulatory shock and its treatment. Lymph and dynamics of lymph flow.
Respiratory system: Anatomical parts of the system, position and function. Mechanics of respiration. Lung volumes and capacities. Gas transport between the Lungs and tissues. Regulation of respiration. Respiratory adjustments in health and diseases.
Digestive system: Different parts of the digestive system. Structure and function of these organs.Digestion of proteins, carbohydrates, fats. Basic mechanism of gastrointestinal absorption of nutrients.
Books:
1. Text book of Medical Physiology, Guyton A.C and J.E. Hall, Harcourt India Pvt. Ltd.
2. Ross and Wilson: Anatomy and Physiology, Churchill Livingstone. 3. Anatomy and Physiology, Gary A. Thibodeau and Kevin T. Patton Mosby.
BM 2102: BIOCHEMISTRY
Introduction: Scope of Biochemistry Carbohydrates: Chemistry, Glycolysis and glycogenolysis, glycogensis, gluconeogenesis, alcoholic fermentation, Krebs cycle, HMP Shunt, ATP Synthesis, regulation of carbohydrate metabolism. Amino Acid: Chemistry properties and metabolism, Urea cycle. Proteins: primary, Secondary, tertiary and quaternary structure, Types and Functions, Synthesis, Purification, Isoenzymes. Lipids: Chemistry, Metabolism of fatty acids, Phospholipids, Cholesterol biosynthesis, regulation of metabolism.
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Nucleic Acid: Chemistry of DNA and RNA, Functions and Genetic Code, Protein Synthesis Enzymes: Classification, Assay, assay, kinetic formulation of Michaels- Mentens equation, mechanism of action, regulation (allosteric and feed back). Vitamins: Structure and functions of vitamins, coenzymes. Hormones: Molecular mechanism of actions (epinephrine or insulin and estradiol or testosterone,) Cyclic AMP and prostaglandins (elementary concepts). Techniques: Centrifugation, chromatography, electrophoresis, tracer methods, spectrophotometer. Balance Diet: Elementary concept
Books: 1. Biochemistry by Champe & Harvey 2. Wilson and Valker: Practical Biochemistry (3rd Ed.), Cambridge Univ. press, 2000 3. Biochemistry by Harper 4. Biochemistry by Stryer 5. Breg et al. Biochemistry (5th Ed.), freeman, 2001
EE 2114 A: ELECTRICAL ENGINEERING
A.C. Circuits: Network element-Voltage and current sources, loop and nodal analysis, Superposition theorem, Thevenin’s theorem. Transient and steady state response of R- L C circuits for step and sinusoidal inputs, impedance concept. Phasor diagram. Single phase series and parallel circuits, resonance . Mutual inductance and coefficient of coupling . Three phase balanced circuits and power measurement.
Electromechanical Energy Converters: Construction, working principles and characteristics of D.C. generators and motors, transformer, three-phase and single-phase induction motors, synchronous generators and motors, universal motors. Starting and speed control of motors. Selection of motors. Principles of power distribution: Introduction with the general layouts of 3 phase distribution systems. House and factory wirings Protection of equipment, Earthing. Elements of power economics: Load and diversity factors. Tariff power factor improvement . Measurements and Instruments: Construction and working principles of ammeter, voltmeter, wattmeter and energy meters, testing and calibration, instrument transformers.
Books: 1. Electric machine I.J. Nagrath and D.P.kothari , Tata Mc Graw Hill 2. Electrical Technology Edward Hugh LBS 8th edition
AM 2101: MATHEMATICAL METHODS
Solution in series, Bessel functions and Legendre function: Self – adjoint differential equations, Power series method of solving second order differential equation, Bessel’s functions of first kind Jn(X), and second kind Yn (x), Recurrence relations, Generating
6

functions of Jn(X), Orthogonal Property of Bessel Functions, Legendre’s equation, Legendre Polynomials Pn (X), Rodrigues formula, Generating function of Pn (X), Orthogonal Property of Pn (X), Sturm-Liouville problem.
Integral Transform: Laplace transform and its properties, Inverse laplace Transform. Use of partial fractions, Convolution theorem. Applications in solving differential equations. Fourier transform and its properties. Inverse Fourier Transform. Convolution theorem. Application of Fourier Transform in solving initial and boundary value problems. Laplace equation. Heat equation and wave equation.
Probability and Statistics: Probability: definitions, addition and multiplication laws, Baye’s Theorem. Random variables Discrete and continuous probability distributions. Binomial, Possion, normal and exponential distributions, mean variance moment Generating function, Characteristic function of a probability distribution. Joint probability distribution of two random variables. Linear regression and correlation analysis .
Books: 1. Advanced Engineering Mathematics by E. Kreyszig, John Wiley & Sons. 2. Advanced Engineering Mathematics by R. K. Jain, S.R.K. Iyenger, Narosa Publishing. 3. Probability and Statistics for engineers by Irwin Miller and John E. Freund, Prentice Hall of India.
MS 2101: INTRODUCTION TO MATERIALS SCIENCE
Classification of engineering materials and their applications: Metals and Alloys, Ceramics and Glasses, Polymers, Composites and Novel Materials. Price and availability of materials. Processing of engineering materials. Chemical bonding and properties of materials: Mechanical, Electrical, Magnetic, Optical, Thermal; Oxidation and degradation behavior of engineering materials. Levels of structure: Nuclear structure, Crystal structure, Nanostructure, Microstructure and Macrostructure. Processing, structure, property correlation.
Books 1. Materials Science & Engineering: An Introduction, W.D. Callister. Jr. 2. Engineering Materials: Properties & Selection, K.G Budinski, M.K. Budinski. 3. The Science and Engineering of Materials, D.R. Askeland. 4. Materials Science and Engineering, V. Raghavan. 5. Engineering Materials Part 1 & 2, Ashby and D.R.H. Jones 6. Understanding Solids, Richard Tilley 7. Properties of Materials, R. E. Newnham.
AC 2101: CHEMISTRY OF POLYMERS
Introduction – Definition, classification, mechanism of polymerization, addition polymerization, condensation polymerization, thermosetting, thermoplastic polymers.
7

Chemical geometrical structures Tg (glass transition temperature) crystallinity of polymers. Chemistry of selected organic polymers, Chemistry of selected inorganic polymers, polymer degradation mechanisms, polymer processing, molecular weight & size of polymer dissolution, thermodynamics of polymers, Florry Huggin theory, viscosity of polymer solution, size and shape of polymers.
Books: 1. Polymer Chemistry an Introduction, R.B. Seymour, C.E. Carraher, E. charles, Marcel Dekker, New York. 2.Principle of Polymer Science, P. Bahadur & N.V. Shastry, Narosa Publishing House, New Delhi. 3. Polymer Science, V.R. Gowariker, N.V. Viswanathan and Jayadev Sreedhar, Halsted Press, John Wiley & Sons, New York. 4. Principles of Polymerization, George Odian, John Wiley & Sons. 4th Ed. 5. Polymer Chemistry, B. Vollmert, Springer-Verlag, Berlin.
4TH – SEMESTER
BM 2201: PHYSIOLOGY-II
Renal system: Parts of the renal system- kidney, ureter, urinary bladder and urethra. Structure and function of parts of the system. Formation and composition of urine. Regulation of acid-base balance. Micturition, diuretics and kidney disease.
Endocrine system and Reproductive system: Elementary knowledge of structure and function of endocrine glands. Functions of male reproductive organs, female reproductive organs & contraception. Nervous Systems: Neuro-anatomy in brief. Receptor, neuron, synapse and reflexes. Neural circuits for processing information. Central nervous system, peripheral nervous system and autonomic nervous system. Neuro chemical environment of brain.Sensory and motor activity of the brain. States of brain activity. Behavioral and motivational activity of brain. Autonomic nervous system. Ventricles and cerebrospinal fluid. Methods to study neural structure and function.
Special Senses: Organs of vision, hearing, taste & smell. Mechanism of vision, color vision, mechanism of hearing, tests of hearing, Physiology of olfaction & smell.
Musculo-skeletal System: Different types of muscles and their characteristics. Structure of bone. Neuro-muscular transmission General description of types of joints, structure and movements. Disorder of joints.
Books: 1. Text book of Medical Physiology by Guyton A.C and J.E. Hall, Harcourt India Pvt. Ltd. 2. Ross and Wilson: Anatomy and Physiology, Ninth Eds. Churchill Livingstone. 3. The Physiological Basis of Medical Practice Charles H. Best
8

4. Anatomy and Physiology, Gary A. Thibodeau and Kevin T. Patton Mosby.
BM 2202 ELECTRONIC DEVICES AND CIRCUITS
Analog electronics: Overview: Passive components, Introduction to Semiconductors. P Type and N type semiconductors, P-N junction, diode characteristics. Zener diode, tunnel diode, LED, photodiodes, Diodes applications as Rectifiers: Half wave rectifiers, full wave rectifiers, their analysis filter and power supplies, voltage regulators(78XX, 79XX, 317 and 337), clippers, clampers, voltage multiplier. Transistor: Basic mechanism of transistor. Characteristics of CB, CC and CE configuration their analysis and frequency response biasing of transistor. Hybrid model power amplifiers push pull amplifiers in class A, class B, class AB; operation feedback in amplifier frequency response. Impedance matching. FET and MOSFET – Basic mechanism structure characteristics and parameters. Digital Electronics: Number system ,Boolean algebra and basic logic gates, combinational logic, Logic families ,encoders decoders and display devices, multiplexers, Demultiplexers , latches and flip flops, counters, shift registers, A/D and D/A converters.
Book list:
1. Digital Principles and applications by A. L Malvino & D. P. Leach. TMH 2. Electronics Principals by A.P. Malvino TMH 3rd ed.
BM 2203 BIOPOTENTIAL
Bio potentials, Resting potential, Action potential, Synaptic Potential-their generation, transmission and propagation. Types and nature of bioelectric signals, interaction of signals to perform various functions of our body. Synaptic transmission and transduction in receptors. Electrical circuit model of the membrane The laws of stimulation and conduction in a nerve impulse. Electrophysiological Signals- ECG, EMG, EEG their generation, propagation, recording and diagnostic applications.
Books
1. Introduction to Neurobiophysics, Vasilescu, D. G. Margineanu, Abacus Press, Tunbridge Wells, Vent.
2. Review of Medical Physiology, W. F. Ganong. 3. Medical Physiology, Guyton.
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4. Medical Physiology, Best and Taylor.
BM 2204: NETWORK ANALYSIS AND SYNTHESIS
Basics of network: Standard input and test signals, voltage and current sources, network elements and types of network. Mesh and Node Analysis, Network theorems. Graph theory: Graph theoretic models of electrical network, incidence Matrix, loop Matrix cut-sets and cut-set matrices, relationship between the matrices, planner graphs and planarity testing algorithms, dual graphs and dual networks, Mesh and node analysis of graph. Network functions: Driving point and transfer function. Two Port Networks: short circuit admittances, open circuit impedances, hybrid parameters, chain parameters, Inverse Transmission parameters, Relationship between parameters, Interconnection of two port networks: Two Port Devices. Analysis of Filters: Classification of filters, constant-k type filters, m-derived filters, composite filters. Network Synthesis: Positive real function, physical realisability conditions, properties of one port immittance functions and their synthesis. Foster and Cauer forms , Two port network synthesis. Books:
1. Network Analysis, M.E Van Valken Berg PHI 3rd edition. 2. Network Analysis and Synthesis, CL Wadhwa, New age 1st ed.
AM 2201: NUMERICAL ANALYSIS
Errors and their estimation. Interpolation: Finite differences: Newton’s forward and backward interpolation formula; Lagrange’s formula; Central differences; Formula of Gauss, Bessel and Everett curve fitting: Method of least squares; Cubic splines. Solution of algebraic and transcendental equations: Iterative methods, Newton-Raphson method, convergence and efficiency of method. Matrices: Eigen value and eigen Vectors, Matrix Decomposition, Inverse of matrix, norm of Matrix. Solution of System of Linear equations: Direct methods: Gauss elimination method, LUDecomposition, Cholesky method, iteration methods: jacobi method, Gauss-Seidel Method; III conditioned systems. Numerical Integration and Differentiation . Numerical solution of ordinary differential equations; Euler method, Modified Euler method and Runga Kutta method . Finite Difference method for solution of boundary value problems of ordinary and partial differential equations.
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School Of Biomedical Engineering Institute Of