Empower Dissolution System Software


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Empower Dissolution System Software
Quick Start Guide
34 Maple Street Milford, MA 01757 71500032203, Revision A

NOTICE
The information in this document is subject to change without notice and should not be construed as a commitment by Waters Corporation. Waters Corporation assumes no responsibility for any errors that may appear in this document. This document is believed to be complete and accurate at the time of publication. In no event shall Waters Corporation be liable for incidental or consequential damages in connection with, or arising from, the use of this document.
© 2002 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA. ALL RIGHTS RESERVED. THIS DOCUMENT OR PARTS THEREOF MAY NOT BE REPRODUCED IN ANY FORM WITHOUT THE WRITTEN PERMISSION OF THE PUBLISHER.
Alliance, Millennium, and Waters are registered trademarks, and Empower, LAC/E, and SAT/IN are trademarks of Waters Corporation. All other trademarks or registered trademarks are the sole property of their respective owners.

Table of Contents
Preface ......................................................................................... 5
Chapter 1 Introduction ...................................................................................... 10
1.1 Dissolution System Features ................................................ 10 1.2 Software Features................................................................. 11 1.3 Tutorial Overview................................................................... 12 1.4 Before You Begin................................................................... 12
Chapter 2 Setting Up the Dissolution System .................................................. 14
2.1 Restoring the Dissolution Project.......................................... 14 2.2 Preparing the Dissolution System......................................... 20 2.3 Preparing to Acquire Dissolution Data .................................. 23
Chapter 3 Developing Methods ........................................................................ 25
3.1 Creating an Instrument Method ............................................ 25 3.2 Creating a Method Set .......................................................... 28 3.3 Creating a Processing Method.............................................. 29
3.3.1 Viewing the Default Processing Method .................... 30 3.3.2 Creating a New Processing Method .......................... 31 3.4 Editing the Method Set.......................................................... 35
Table of Contents 3

Chapter 4 Developing and Running a Sample Set Method for Dissolution Testing ............................................................................................ 37
4.1 Viewing the Default Dissolution Sample Set Method ............ 37 4.2 Creating a Dissolution Sample Set Method .......................... 38 4.3 Running a Dissolution Sample Set Method .......................... 47 Chapter 5 Reviewing Results and Generating Reports .................................... 53 5.1 Reviewing Results................................................................. 53
5.1.1 Displaying the Dissolution Results............................. 53 5.2 Generating a Report ............................................................. 55
Table of Contents 4

Preface

The Empower Dissolution System Software Quick Start Guide describes the basics of how to use the Empower™ software and the Empower Dissolution software option with a Waters Alliance Dissolution System or another dissolution system. Using a standard set of data, this guide leads you through the steps of logging in, acquiring data, developing methods and method sets, reviewing processed data, and printing reports.
Most procedures in this guide are based on use of the Waters Alliance Dissolution System and one Hanson SR8-Plus bath. However, you can use these procedures for reference when using two Hanson SR8-Plus test baths or with other dissolution systems.
Note: If you use a non-Waters dissolution system, you can use the Empower Dissolution software option only to process dissolution test results.
For in-depth explanations of the Empower software theories of data acquisition, peak detection, integration, and quantitation, refer to the Empower Software Data Acquisition and Processing Theory Guide.

STOP

Attention: Before you use the Empower Dissolution software option, become familiar with the procedures for methods development explained in the Empower Help and in the Empower Software Getting Started Guide. Additionally, if you use the Waters Alliance Dissolution System, become familiar with the procedures in the Waters Alliance Dissolution System Operator’s Guide.

This guide is intended for both novice and experienced users of the Waters Alliance Dissolution System and the Empower software.
Organization
This guide contains the following:
Chapter 1 describes the basic functions of the Empower Dissolution Software option and how it works with the Waters Alliance Dissolution System and other dissolution systems.
Chapter 2 describes how to restore the default dissolution project, and make a working copy of the restored project to use in the tutorials.
Chapter 3 describes how to develop a dissolution instrument method, a dissolution method set, and a dissolution processing method using the Empower software.
Chapter 4 describes how to develop a dissolution sample set method to acquire dissolution data and how to run a dissolution test.
Chapter 5 describes how to review dissolution data and preview, edit, and print a dissolution plot and report.

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Related Documentation
Waters Licenses, Warranties, and Support: Provides software license and warranty information, describes training and extended support, and tells how Waters handles shipments, damages, claims, and returns.
Online Documentation
Empower Help: Describes all Empower windows, menus, menu selections, and dialog boxes for the base software and software options. Also includes reference information and procedures for performing all tasks required to use Empower software. Included as part of the Empower software.
Empower Read Me File: Describes product features and enhancements, helpful tips, installation and/or configuration considerations, and changes since the previous version.
Empower LIMS Help: Describes how to use the Empower LIMS Interface to export results and import worklists.
Empower Toolkit Professional Help: Describes how to use the common-objectmodel, message-based protocol to communicate with the Empower software from a third-party application.
Printed Documentation for Base Product
Empower Software Getting Started Guide: Provides an introduction to the Empower software. Describes the basics of how to use Empower software to acquire data, develop a processing method, review results, and print a report. Also covers basic information for managing projects and configuring systems.
Empower Software Data Acquisition and Processing Theory Guide: Provides theories pertaining to data acquisition, peak detection and integration, and quantitation of sample components.
Empower System Installation and Configuration Guide: Describes Empower software installation, including the stand-alone Personal workstation, Workgroup configuration, and the Enterprise client/server system. Discusses how to configure the computer and chromatographic instruments as part of the Empower System. Also covers the installation, configuration, and use of acquisition servers such as the LAC/E32 module, the busLAC/E™ card, and interface cards used to communicate with serial instruments.
Empower System Upgrade and Configuration Guide: Describes how to add hardware and upgrade the Empower software using an import-and-export upgrade method.
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Empower Software System Administrator’s Guide: Describes how to administer the Empower Enterprise client/server system and Workgroup configuration.
Empower Software Release Notes: Contains last-minute information about the product. Also provides supplementary information about specific Empower software releases.
Printed Documentation for Software Options
Empower System Suitability Quick Reference Guide: Describes the basics of the Empower System Suitability option and describes the equations used by the System Suitability software.
Empower PDA Software Getting Started Guide: Describes the basics of how to use the Empower PDA option to develop a PDA processing method and to review PDA results.
Empower GC Software Getting Started Guide: Describes how to use the Empower GC option to develop a GC processing method and to review GC results.
Empower GPC Software Getting Started Guide: Describes how to use the Empower GPC option to develop a GPC processing method and to review GPC results.
Empower GPCV Software Getting Started Guide: Describes how to use the Empower GPCV option to develop a GPCV processing method and to review GPCV results.
Empower Light Scattering Software Getting Started Guide: Describes how to use the Empower Light Scattering option to develop a light scattering processing method and to review light scattering results.
Empower ZQ Mass Detector Software Getting Started Guide: Describes installation, configuration, calibration, and tuning methods, as well as how to operate the ZQ Mass Detector with Empower software.
Empower Chromatographic Pattern Matching Software Getting Started Guide: Describes how to use the Chromatographic Pattern Matching option to develop a pattern matching processing method and to review pattern matching results.
Empower Dissolution System Software Quick Start Guide: Describes how to operate the Alliance® Dissolution System using Empower software.
Empower Toolkit Programmer’s Reference Guide: Describes how to use the common-object-model, message-based protocol to communicate with Empower software from a third-party application.
Waters Integrity System Getting Started Guide: Describes features of the Waters Integrity® System and provides step-by-step tutorials that guide a user through the use of the Empower Mass Spectrometry (MS) option.
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Empower AutoArchive Software Installation and Configuration Guide: Describes how to install and configure the Empower AutoArchive option.
Documentation on the Web
Related product information and documentation can be found on the World Wide Web. Our address is http://www.waters.com.
Related Adobe Acrobat Reader Documentation
For detailed information about using Adobe® Acrobat® Reader, see the Adobe Acrobat Reader Online Guide. This guide covers procedures such as viewing, navigating, and printing electronic documentation from Adobe Acrobat Reader.
Printing This Electronic Document
Adobe Acrobat Reader lets you easily print pages, page ranges, or the entire document by selecting File > Print. For optimum print quantity, Waters recommends that you specify a PostScript® printer driver for your printer. Ideally, use a printer that supports 600 dpi print resolution.
Documentation Conventions
The following conventions can be used in this guide:

Convention Purple
Italic
Courier Courier Bold
Underlined Blue

Usage
Purple text indicates user action such as keys to press, menu selections, and commands. For example, “Click Next to go to the next page.”
Italic indicates information that you supply such as variables. It also indicates emphasis and document titles. For example, “Replace file_name with the actual name of your file.”
Courier indicates examples of source code and system output. For example, “The SVRMGR> prompt appears.”
Courier bold indicates characters that you type or keys you press in examples of source code. For example, “At the LSNRCTL> prompt, enter set password oracle to access Oracle.”
Indicates hypertext cross-references to a specific chapter, section, subsection, or sidehead. Clicking this topic using the hand symbol brings you to this topic within the document. Right-clicking and selecting Go Back from the shortcut menu returns you to the originating topic. For example, “After you create an instrument method, a processing method, and a method set, you can create a sample set method as described in Section 4.2, Creating a Dissolution Sample Set Method.”

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Convention Keys
… >

Usage
The word key refers to a computer key on the keypad or keyboard. Screen keys refer to the keys on the instrument located immediately below the screen. For example, “The A/B screen key on the 2414 Detector displays the selected channel.”
Three periods indicate that more of the same type of item can optionally follow. For example, “You can store filename1, filename2, … in each folder.”
A right arrow between menu options indicates you should choose each option in sequence. For example, “Select File > Exit” means you should select File from the menu bar, then select Exit from the File menu.

Notes Notes call out information that is helpful to the operator. For example: Note: Record your result before you proceed to the next step.
Attentions Attentions provide information about preventing damage to the system or equipment. For example:
Attention: To avoid damaging the detector flow cell, do not touch the flow cell STOP window.

Cautions Cautions provide information essential to the safety of the operator. For example:
Caution: To avoid burns, turn off the lamp at least 30 minutes before removing it for replacement or adjustment.

Caution: To avoid electrical shock and injury, turn off the detector and unplug the power cord before performing maintenance procedures.
Caution: To avoid chemical or electrical hazards, observe safe laboratory practices when operating the system.

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Chapter 1 Introduction
This quick start guide describes the basic procedures to set up for a dissolution test. You should be familiar with the operation of the Waters® Alliance® Dissolution System, which consists of:
• A Waters 2690D/2695D Separations Module (6- or 8-needle) • A Waters Transfer Module (6- or 8-syringe) • One or two Hanson SR8-Plus baths (optional)
Attention: You cannot perform dissolution testing using a 6-needle 2690D/2695D STOP Separations Module with an 8-syringe transfer module, or vice versa.
For information on operating the Waters Alliance Dissolution System, refer to the Waters Alliance Dissolution System Operator’s Guide. If you do not use a Waters Alliance Dissolution System, you can use or adapt the procedures in this guide for your system.
1.1 Dissolution System Features
The Empower Dissolution option is used with the Waters Alliance Dissolution System or with any other HPLC-based dissolution system. When used with the Waters Alliance Dissolution System, the dissolution software option allows you to acquire, process, review, and report dissolution test data. It provides dissolution-specific functions, such as a Compute Dissolution algorithm to calculate the amount and percent dissolved for each component peak, and a Dissolution Wait time so you can specify injection of standards immediately before sample transfers. For more information on the Empower Dissolution option functions, see the “Dissolution Functions (Samples Table)” topic in the Empower Help. For more information on dissolution calculations used in the Empower Dissolution option, see the “Compute Dissolution Algorithm” topic in the Empower Help. If you use one or two Hanson SR8-Plus test baths with the Alliance Dissolution System, the Dissolution software option also controls the bath temperature and apparatus speed, as well as sample transfer, injection, review, report, and processing.
Dissolution System Features 10

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Empower Dissolution System Software