Primary (& Secondary) Appointment Name (s) Research Interest

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Name Blobe, Gerard / M.D., Ph.D. Caron, Marc / Ph.D. Chi, Jen-Tsan Ashley / M.D., Ph.D. Counter, Christopher / Ph.D. Diehl, Anna Mae / M.D. Fox, Donald/ Ph.D.
Goetz, Sarah C. / Ph.D. Gromeier, Matthias / Ph.D.
Hirschey, Matthew / Ph.D. Huang, Jiaoti / M.D., Ph.D.
Kastan, Michael / M.D., Ph.D. Kirsch, David / M.D., Ph.D. Kontos, Christopher / M.D.

Primary (& Secondary) Appointment (s)
Medicine (Pharmacology and Cancer Biology) Cell Biology
Molecular Genetics and Microbiology (Institute of Genome, Science and Policy) Pharmacology and Cancer Biology (Radiation Oncology) Medicine Pharmacology and Cancer Biology
Pharmacology and Cancer Biology
Surgery-Neuro-Oncology (Medicine, Molecular Genetics and Microbiology)
Medicine (Pharmacology and Cancer Biology) Pathology (Pharmacology and Cancer Biology)
Pharmacology and Cancer Biology
Radiation Oncology (Pharmacology and Cancer Biology) Medicine (Pharmacology and Cancer Biology)

Research Interest
Role of transforming growth factor-beta (TGF-beta) superfamily signaling pathways in cancer biology.
Molecular and cellular mechanisms by which G protein-coupled receptors control normal and abnormal physiological functions.
The use of genomic tools to enhance the understanding of human diseases and disease-related biological questions.
Molecular analysis of Ras signaling in cancer.
Liver injury and repair.
We study polyploidy- the acquisition of extra genome sets. Using Drosophila genetics, we study how polyploidy can both destabilize the genome during mitosis and promote tissue repair when mitosis is impaired.
The role of primary cilia-mediated cell signaling in development and disease.
Mechanisms of protein synthesis regulation and ways to exploit abnormal signal transduction to translation machinery for cancer treatment.
Mitochondrial function and small metabolite regulation of nutrient metabolism by post-translational modifications.
Our lab’s research focuses on prostate cancer including molecular mechanisms of carcinogenesis, therapeutic resistance and disease progression. We are particularly interested in biomarkers, imaging and novel treatment strategies.
Molecular and cellular responses to DNA damage and other stresses.
Modeling cancer in the mouse and mechanisms of DNA damage response after radiation.
Molecular mechanisms of vascular remodeling in cardiovascular diseases, including tumor angiogenesis, with emphasis on signaling by endothelial receptor tyrosine kinases.

Name Lefkowitz, Robert / M.D. Lew, Daniel / Ph.D. Li, Chuan-Yuan / Ph.D. Li, Qi-Jing / Ph.D. Linardic, Corinne / M.D., Ph.D. Locasale, Jason / Ph.D. Luftig, Micah / Ph.D.
MacAlpine, David / Ph.D.
McDonnell, Donald / Ph.D.
Murphy, Susan / Ph.D.
Patz, Edward Jr. / M.D.

Primary (& Secondary) Appointment (s)
Medicine (Biochemistry, Immunology)
Pharmacology and Cancer Biology (Molecular Genetics and Microbiology) Dermatology (Pharmacology and Cancer Biology) Immunology; (Duke Cancer Institute)
Pediatrics (Pharmacology and Cancer Biology) Pharmacology and Cancer Biology
Molecular Genetics and Microbiology
Pharmacology and Cancer Biology
Pharmacology and Cancer Biology (Medicine)
Obstetrics and Gynecology
Radiology (Pathology, Pharmacology and Cancer Biology)

Research Interest
Molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors.
Cell cycle control and the control of cell polarity.
Mechanisms of sarcomagenesis; senescence; modeling cancer from primary human cells.
microRNA-mediated immunoregulation in T lymphocytes and cancer immunotherapy.
Mechanisms of sarcomagenesis; senescence; modeling cancer from primary human cells.
Understanding metabolism and its contribution to human cancer pathogenesis.
Mechanisms by which Epstein-Barr virus activates and ultimately subverts the host oncogenic stress response to growth transform primary B lymphocytes into indefinitely proliferating lymphoblastoid cell lines (LCLs).
Understanding the mechanisms by which the molecular architecture of the chromosome regulates fundamental biological processes such as replication and transcription.
Identify druggable targets within estrogen- and androgenregulated signal transduction pathways that can be exploited in the development of novel breast and prostate cancer therapeutics.
Epigenetic alterations in gynecologic malignancies, cancer stem cells, preclinical studies of novel therapeutics, role of epigenetics in the early origins of disease.
Translational issues related to early cancer detection and mechanisms of metastasis.

Name Pendergast, Ann Marie / Ph.D.
Petes, Thomas / Ph.D. Sampson, John / M.D., PhD., M.H.Sc. Sherwood, David / Ph.D. Sipkins, Dorothy / M.D., PhD.
Sullivan, Beth / Ph.D.
Tsvetanova, Nikoleta (Nina) / Ph.D. Wang, Xiao Fan / Ph.D.

Primary (& Secondary) Appointment (s)
Pharmacology and Cancer Biology
Molecular Genetics and Microbiology Surgery (Pathology, Immunology, Radiation Oncology) Biology Medicine (Pharmacology and Cancer Biology)
Molecular Genetics and Microbiology
Pharmacology and Cancer Biology
Pharmacology and Cancer Biology

Research Interest
We seek to define the role of protein tyrosine phosphorylation and transcription factor networks in cancer and the response to injury and regeneration. Specifically, we are currently using state-of-the art transcriptomic technologies to discover actionable networks that promote lung and breast cancer metastasis to the brain and other organs, as well as mediate the crosstalk of cancer cells with immune and other cell types in the tumor microenvironment. Together these studies will provide molecular understanding of the mechanisms that promote tumor metastasis, leading to the discovery of novels therapies.
The genetic regulation of genome stability and the mechanism of mitotic recombination.
We derive novel mechanisms of immunotherapy for cancer and develop drugs for translation into humans. We also study the delivery of therapeutics into the central nervous system.
Using live-cell imaging, molecular genetics and systems level approaches in C. elegans to understand cell invasive behavior.
Tumor microenvironment interactions that regulate cancer metastasis, dormancy and therapy evasion. We use classical molecular and cell biology techniques as well as real-time, in vivo microscopy to investigate tumor-host cross-talk in mouse models of leukemia and breast cancer.”
The Sullivan Lab is focused on chromosome organization, with a specific emphasis on the genomics and epigenetics of the chromosomal locus called the centromere and the formation and fate of chromosome abnormalities that are associated with birth defects, reproductive abnormalities, and cancer.
We study the biochemical and spatial regulation of GPCR signaling networks and their impact on physiology, using a combination of high-throughput quantitative approaches and cell biology techniques.
Molecular nature and signaling mechanism of tumor microenvironment associated with tumor progression and metastasis.

Name Wingler, Laura / Ph.D. Wood, Kris / Ph.D. Wu, Colleen / Ph.D.
Yan, Hai / M.D., Ph.D. Yao, Tso-Pang / Ph.D. Zhang, Zhao (ZZ) / Ph.D.
Zhuang, Yuan / Ph.D.

Primary (& Secondary) Appointment (s)
Pharmacology and Cancer Biology Pharmacology and Cancer Biology Orthopaedic Surgery
Pathology Pharmacology and Cancer Biology Pharmacology and Cancer Biology

Research Interest
Studies G protein-coupled receptor (GPCR) activation.
New functional genomics technologies and their applications in basic and translational cancer biology.
The Wu lab seeks to understand how hypoxia (low oxygen) and hypoxia inducible signaling (HIF) signaling regulates cells in the bone microenvironment to control tissue homeostasis and to contribute to metastatic colonization of the bone.
Cancer genomics and signaling pathways that control tumorigenesis.
Identify and reconstruct the fundamental steps leading to physiological aging and devise therapeutic solutions.
We investigate the impact and regulation of transposons in both reproductive and somatic tissues, aiming to uncover their influence on reproduction, development, and disease, such as cancer.
Genetic analysis of lymphocyte development and lymphoid system diseases.

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Primary (& Secondary) Appointment Name (s) Research Interest